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Sci. STKE, 23 October 2001
Vol. 2001, Issue 105, p. tw395
[DOI: 10.1126/stke.2001.105.tw395]


Cancer {gamma}{delta} T Cells Get Under the Skin

T cells bearing the {gamma}{delta} T cell receptor reside in large numbers within the epidermis of the skin. The growing evidence that {gamma}{delta} T cells contribute to dermal integrity is supported by the study by Girardi et al., who show these lymphocytes can protect against cutaneous malignancy. Thus, in the absence of {gamma}{delta} T cells, mice coped poorly with experimentally induced forms of skin carcinoma. Induction of malignancy correlated with the increased amounts of the protein Rae-1, which contributed to the killing of carcinoma cells by a {gamma}{delta} T cell line in vitro. Binding studies revealed that Rae-1 interacts with the NKG2d receptor on {gamma}{delta} T cells, which suggests that this ligand may be a functional homolog of tumor-related MICA/B proteins in humans. Pardoll provides a Perspective on the article.

M. Girardi, D. E. Oppenheim, C. R. Steele, J. M. Lewis, E. Glusac, R. Filler, P. Hobby, B. Sutton, R. E. Tigelaar, A. C. Hayday, Regulation of cutaneous malignancy by {gamma}{delta} T cells. Science 294, 605-609 (2001). [Abstract] [Full Text]

D. M. Pardoll, Stress, NK receptors, and immune surveillance. Science 294, 534-536 (2001). [Full Text]

Citation: {gamma}{delta} T Cells Get Under the Skin. Sci. STKE 2001, tw395 (2001).

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