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Sci. STKE, 16 January 2001
Vol. 2001, Issue 65, p. pe1
[DOI: 10.1126/stke.2001.65.pe1]

PERSPECTIVES

New Responsibilities for the PI3K Regulatory Subunit p85{alpha}

Klaus Okkenhaug, and Bart Vanhaesebroeck

The authors are at the Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 8BT, UK. E-mail: klaus{at}ludwig.ucl.ac.uk, bartvanh{at}ludwig.ucl.ac.uk

Abstract:

Class IA phosphoinositide-3 kinases (PI3Ks) are heterodimeric enzymes that regulate many signal transduction pathways. The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids. Recent studies present evidence for an additional role for p85{alpha} in the regulation of actin cytoskeleton. Okkenhaug and Vanhaesebroeck discuss these results and ask whether experiments describing p85{alpha} knockout mice need to be reinterpreted.

Citation:
K. Okkenhaug, B. Vanhaesebroeck, New Responsibilities for the PI3K Regulatory Subunit p85{alpha} . Science's STKE (2001), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/65/pe1.

© 2001 American Association for the Advancement of Science

Citation: K. Okkenhaug, B. Vanhaesebroeck, New Responsibilities for the PI3K Regulatory Subunit p85{alpha} . Sci. STKE 2001, pe1 (2001).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit.
N. Miled, Y. Yan, W.-C. Hon, O. Perisic, M. Zvelebil, Y. Inbar, D. Schneidman-Duhovny, H. J. Wolfson, J. M. Backer, and R. L. Williams (2007)
Science 317, 239-242
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