New Responsibilities for the PI3K Regulatory Subunit p85{alpha}

doi:10.1126/stke.2001.65.pe1

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Sci. STKE, 16 January 2001
Vol. 2001, Issue 65, p. pe1
[DOI: 10.1126/stke.2001.65.pe1]

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New Responsibilities for the PI3K Regulatory Subunit p85 ${alpha}$

Klaus Okkenhaug, and Bart Vanhaesebroeck

The authors are at the Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 8BT, UK. E-mail: klaus{at}ludwig.ucl.ac.uk, bartvanh{at}ludwig.ucl.ac.uk

Abstract:

Class IA phosphoinositide-3 kinases (PI3Ks) are heterodimericenzymes that regulate many signal transduction pathways. Thep85 regulatory subunit recruits the p110 catalytic subunit tothe membrane, where p110 phosphorylates inositol lipids. Recentstudies present evidence for an additional role for p85 ${alpha}$ in theregulation of actin cytoskeleton. Okkenhaug and Vanhaesebroeckdiscuss these results and ask whether experiments describingp85 ${alpha}$ knockout mice need to be reinterpreted.

Citation:
K. Okkenhaug, B. Vanhaesebroeck, New Responsibilities for the PI3K Regulatory Subunit p85 ${alpha}$ . Science's STKE (2001), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/65/pe1.

Citation: K. Okkenhaug, B. Vanhaesebroeck, New Responsibilities for the PI3K Regulatory Subunit p85 ${alpha}$ . Sci. STKE 2001, pe1 (2001).

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