Sci. STKE, 13 February 2001
Channels Kinase and Channel in One Package
An ion channel that contains its own functional protein kinase domain has been cloned and characterized by Runnels et al. The channel, called TRP-PLIK, is most closely related to melastatin, a channel protein associated with progression of melanocytic tumors. TRP-PLIK also appears to interact with the key signaling enzyme phospholipase C-β1. Mutagenesis studies of the kinase domain and the dependence of channel conductance on intracellular adenosine triphosphate both indicate that the kinase activity of the channel regulates channel function. This channel likely links signaling from the cell membrane to the control of proliferation or of other calcium-dependent processes within the cell.
Citation: Kinase and Channel in One Package. Sci. STKE 2001, tw8 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882