Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 27 February 2001
Vol. 2001, Issue 71, p. pe1
[DOI: 10.1126/stke.2001.71.pe1]

A Progress Report on Translational Control in Eukaryotes

Marilyn Kozak*

The author is in the Department of Biochemistry, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.

Abstract: An extraordinary amount of regulation goes into making sure that protein expression is controlled correctly. Several layers of regulation function to achieve the proper levels and proper timing of protein expression. Much is known about the protein machinery involved in translation, but we are lagging behind in understanding the mechanisms of control in eukaryotes. Kozak reviews the new second edition of Translational Control of Gene Expression, which attempts to catalog the mechanisms used by prokaryotes and eukaryotes, and the viruses that infect them and subvert their translational machinery.

Review and commentary on Translational Control of Gene Expression Edited by Nahum Sonenberg, John W. B. Hershey, and Michael B. Mathews Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 2000, 1020 pp. $115 ISBN: 0-87969-568-4

Corresponding author. E-mail: kozakma{at}

Citation: M. Kozak, A Progress Report on Translational Control in Eukaryotes. Sci. STKE 2001, pe1 (2001).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882