Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 27 February 2001
Vol. 2001, Issue 71, p. tw3
[DOI: 10.1126/stke.2001.71.tw3]


Immunology Antigen Recognition Cuts Both Ways

B cells appropriate help from T cells by expressing class II molecules, which display antigenic peptides to specific receptors expressed by the T cells. These receptors are wired up to complex intracellular signaling pathways that launch a program of activation and differentiation in the T cell upon the recognition of appropriate antigen. Lang et al. provide evidence that the interaction between T cell receptor and class II molecule is not simply a one-way exchange of information. Signals could be delivered back to the B cell via the class II molecules. This process depended on their association with the signaling chains of the B cell antigen receptor. This process may play a role in regulating T cell-B cell cooperation during immune responses to antigen.

P. Lang, J. C. Stolpa, B. A. Freiberg, F. Crawford, J. Kappler, A. Kupfer, J. C. Cambier, TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-α/β dimers. Science 291, 1537-1540 (2001). [Abstract] [Full Text]

Citation: Antigen Recognition Cuts Both Ways. Sci. STKE 2001, tw3 (2001).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882