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Sci. STKE, 6 March 2001
Vol. 2001, Issue 72, p. tw10
[DOI: 10.1126/stke.2001.72.tw10]


Nuclear Receptors Fatty Acid Shuttle

Peroxisome proliferator-activated receptors (PPARα, PPARβ, and PPAR{gamma}) are transcription factors activated by fatty acids and some antidiabetogenic drugs. Wolfrum et al. identified liver fatty acid binding protein (LFABP) as a protein that binds to the same ligands as does PPARα and that interacts directly with PPARα and PPAR{gamma}. They propose that LFABP, which can be found in both the cytoplasm and the nucleus, acts as a shuttle to deliver the PPAR agonists to the nuclear-localized PPAR receptors. In support of this model, transactivation of a PPAR reporter construct increased linearly with the amount of LFABP expressed.

C. Wolfrum, C. M. Borrmann, T. Börchers, F. Spener, Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and {gamma}-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus. Proc. Natl. Acad. Sci. U.S.A. 98, 2323-2328 (2001). [Abstract] [Full Text]

Citation: Fatty Acid Shuttle. Sci. STKE 2001, tw10 (2001).

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