Sci. STKE, 6 March 2001
Nuclear Receptors Fatty Acid Shuttle
Peroxisome proliferator-activated receptors (PPARα, PPARβ, and PPAR) are transcription factors activated by fatty acids and some antidiabetogenic drugs. Wolfrum et al. identified liver fatty acid binding protein (LFABP) as a protein that binds to the same ligands as does PPARα and that interacts directly with PPARα and PPAR. They propose that LFABP, which can be found in both the cytoplasm and the nucleus, acts as a shuttle to deliver the PPAR agonists to the nuclear-localized PPAR receptors. In support of this model, transactivation of a PPAR reporter construct increased linearly with the amount of LFABP expressed.
C. Wolfrum, C. M. Borrmann, T. Börchers, F. Spener, Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and -mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus. Proc. Natl. Acad. Sci. U.S.A. 98, 2323-2328 (2001). [Abstract] [Full Text]
Citation: Fatty Acid Shuttle. Sci. STKE 2001, tw10 (2001).
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