Sci. STKE, 6 March 2001
Structural Biology How to Grab a Membrane
After endocytosis, endosomes fuse with one another. One targeting factor appears to be the production of phosphatidylinositol 3-phosphate in membranes; this lipid head group is then recognized by so-called FYVE domains found on some endosomal fusion proteins. Kutateladze and Overduin present an analysis of the structure of the FYVE domain of early endosome antigen 1 in complex with phosphatidylinositol 3-phosphate and suggest a mechanism by which these interactions may promote endosome recognition. For an excellent overview on how FYVE domains function in signaling, read the STKE perspective by Corvera.
S. Corvera, Signal transduction: Stuck with FYVE domains. Science's STKE (2000), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2000/37/pe1 [Full Text]
Citation: How to Grab a Membrane. Sci. STKE 2001, tw8 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882