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Sci. STKE, 13 March 2001
Vol. 2001, Issue 73, p. pe1
[DOI: 10.1126/scisignal.732001pe1]

PERSPECTIVES

Two Mammalian Mitotic Aurora Kinases: Who's Who?

Simon Descamps and Claude Prigent

The authors are at the Groupe Cycle Cellulaire, UMR 6061 Génétique et Développement, CNRS-Université de Rennes I, IFR 97 Génomique Fonctionnelle et Santé, Faculté de Médecine, 2 avenue du Pr Léon Bernard, CS 34317, 35043 Rennes cedex, France. E-mail: claude.prigent{at}univ-rennes1.fr

Abstract: Several serine-threonine kinases related to the Ipl1p kinase in budding yeast, termed aurora kinases, have been cloned recently. Their characterization revealed them to be important regulators of mitotic functions, including (i) the separation of the centrosome, (ii) assembly of the spindles, and (iii) segregation of the chromosomes. The Perspective by Descamps and Prigent delves into the latest observations on aurora kinases in humans and the specific roles of each kinase within the process of mitosis.

Citation: S. Descamps, C. Prigent, Two Mammalian Mitotic Aurora Kinases: Who's Who? Sci. STKE 2001, pe1 (2001).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882