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Sci. STKE, 20 March 2001
Vol. 2001, Issue 74, p. tw10
[DOI: 10.1126/stke.2001.74.tw10]


Developmental Biology Brains Take Shape

What gives a tissue or organ its stereotypic size, shape, and orientation? Experiments by Agarwala et al. now help to elucidate the molecular mechanism underlying the formation of different brain tissues. They altered the size, shape, and orientation of the Sonic Hedgehog morphogen in the developing chick brain and show that this signaling molecule can control the size, shape, and orientation of characteristic brain structures.

S. Agarwala, T. A. Sanders, C. W. Ragsdale, Sonic hedgehog control of size and shape in midbrain pattern formation. Science 291, 2147-2150 (2001). [Abstract] [Full Text]

Citation: Brains Take Shape. Sci. STKE 2001, tw10 (2001).

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