Sci. STKE, 20 March 2001
Virology Follow the Template
Cytokines bind to the receptor gp130 and activate a variety of intracellular responses. Chow et al. have determined a 2.4 angstrom-resolution structure of the ligand-binding and activation domains of gp130 bound to Karposi's sarcoma-associated herpesvirus interleukin-6 (IL-6). A tetrameric signaling complex is formed by interactions between viral IL-6 and the activation domain of human gp130. This assembly reveals why the activation domain is required for formation of a competent signaling complex. The tetramer provides a template to model the hexameric signaling complexes formed between gp130 and human cytokines and shows how the viral cytokine achieves molecular mimicry.
Citation: Follow the Template. Sci. STKE 2001, tw12 (2001).
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