Sci. STKE, 20 March 2001
Cell Biology Doing More than Locomotion
The major sperm cytoskeletal protein (MSP) functions in the crucial role of locomotion. Miller et al. found that, in the nematode, MSP also executes another critical step in reproduction: inducing the female's oocyte to come out of the arrest phase and to mature. These results suggest that other proteins with MSP-like domains, which are found in plants, fungi, and other animals, may also have a signaling role. Villeneuve provides a Perspective on the work done by Miller et al.
M. A. Miller, V. Q. Nguyen, M.-H. Lee, M. Kosinski, T. Schedl, R. M. Caprioli, D. Greenstein, A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation. Science 291, 2144-2147 (2001). [Abstract] [Full Text]
A. M. Villeneuve, How to stimulate your partner. Science 291, 2099-2101 (2001). [Full Text]
Citation: Doing More than Locomotion. Sci. STKE 2001, tw13 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882