Sci. STKE, 27 March 2001
Neurobiology Learning and Relearning
Experimental extinction, the disappearance of a conditioned behavior after repetitive trials in the absence of the unconditioned stimulus, is not simply a kind of forgetting but rather a new learning phenomenon. To address the cellular mechanisms underlying this phenomenon, Berman and Dudai studied conditioned taste aversion in the rat insular cortex. Both acquisition and extinction of conditioned taste aversion were impaired by inhibition of protein synthesis and involved β-adrenergic receptor activation. Acquisition, but not extinction, was decreased by antagonists of muscarinic receptors and N-methyl-D-aspartate receptors and also by mitogen-activated protein kinase inhibitors. There are thus clear differences between memory encoding and consolidation during retrieval.
Citation: Learning and Relearning. Sci. STKE 2001, tw8 (2001).
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