Sci. STKE, 17 April 2001
Aging Insulin-Like Pathways and Aging
In the nematode Caenorhabditis elegans, mutations in the daf pathway, which normally regulates an inactive hibernation-like life phase, can prolong life-span dramatically. The daf pathway is homologous to the insulin pathway of higher organisms, and the ability of caloric restriction to increase the life-span of rodents suggests further links. Fabrizio et al. take this demonstration a step further by screening for mutants that control life-span in nonreplicating yeast. They identify Sch9, a kinase similar to the Akt/PKB kinase in the insulin signaling pathway of mammals, as well as the yeast homolog of adenylate cyclase. The insulin-like signaling pathway appears to be a prime regulator of life-span, likely through its control of whole-organism metabolism.
Citation: Insulin-Like Pathways and Aging. Sci. STKE 2001, tw10 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882