Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 17 April 2001
Vol. 2001, Issue 78, p. tw10
[DOI: 10.1126/stke.2001.78.tw10]

EDITORS' CHOICE

Aging Insulin-Like Pathways and Aging

In the nematode Caenorhabditis elegans, mutations in the daf pathway, which normally regulates an inactive hibernation-like life phase, can prolong life-span dramatically. The daf pathway is homologous to the insulin pathway of higher organisms, and the ability of caloric restriction to increase the life-span of rodents suggests further links. Fabrizio et al. take this demonstration a step further by screening for mutants that control life-span in nonreplicating yeast. They identify Sch9, a kinase similar to the Akt/PKB kinase in the insulin signaling pathway of mammals, as well as the yeast homolog of adenylate cyclase. The insulin-like signaling pathway appears to be a prime regulator of life-span, likely through its control of whole-organism metabolism.

P. Fabrizio, F. Pozza, S. D. Pletcher, C. M. Gendron, V. D. Longo, Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290 (2001). [Abstract] [Full Text]

Citation: Insulin-Like Pathways and Aging. Sci. STKE 2001, tw10 (2001).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882