Sci. STKE, 17 April 2001
Neurobiology G proteins and Presynaptic Inhibition
Several neurotransmitters modulate synaptic release from presynaptic terminals by activating G-protein-coupled receptors. Blackmer et al. investigated the basic mechanisms underlying this modulation of the exocytotic machinery in neurons. Microinjection of G-protein ß-subunits (Gß) into lamprey reticulospinal axons inhibited synaptic transmission without decreasing the action potential-dependent influx of Ca2+. This result suggests a potentially new effector role for Gß through directly modulating the vesicle fusion machinery in the synaptic terminal.
T. Blackmer, E. C. Larsen, M. Takahashi, T. F. J. Martin, S. Alford, H. E. Hamm, G protein ß subunit-mediated presynaptic inhibition: Regulation of exocytotic fusion downstream of Ca2+ entry. Science 292, 293-297 (2001). [Abstract] [Full Text]
Citation: G proteins and Presynaptic Inhibition. Sci. STKE 2001, tw5 (2001).
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