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Sci. STKE, 17 April 2001
Vol. 2001, Issue 78, p. tw5
[DOI: 10.1126/scisignal.782001tw5]

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Neurobiology G proteins and Presynaptic Inhibition

Several neurotransmitters modulate synaptic release from presynaptic terminals by activating G-protein-coupled receptors. Blackmer et al. investigated the basic mechanisms underlying this modulation of the exocytotic machinery in neurons. Microinjection of G-protein ß{gamma}-subunits (Gß{gamma}) into lamprey reticulospinal axons inhibited synaptic transmission without decreasing the action potential-dependent influx of Ca2+. This result suggests a potentially new effector role for Gß{gamma} through directly modulating the vesicle fusion machinery in the synaptic terminal.

T. Blackmer, E. C. Larsen, M. Takahashi, T. F. J. Martin, S. Alford, H. E. Hamm, G protein ß{gamma} subunit-mediated presynaptic inhibition: Regulation of exocytotic fusion downstream of Ca2+ entry. Science 292, 293-297 (2001). [Abstract] [Full Text]

Citation: G proteins and Presynaptic Inhibition. Sci. STKE 2001, tw5 (2001).

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