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Sci. STKE, 24 April 2001
Vol. 2001, Issue 79, p. pe1
[DOI: 10.1126/stke.2001.79.pe1]


A New Role for Protein Methylation: Switching Partners at the Phosphatase Ball

Marc Mumby

The author is in the Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041, USA. E-mail: marc.mumby{at}

Abstract: Reversible protein methylation may be another posttranslational modification that serves an important role in modulating signal transduction pathways. Not only does protein phosphatase 2A (PP2A), a key regulator of many signal transduction cascades, undergo this modification, but the methylation process itself may be regulated by various cellular stimuli or states. Mumby describes how PP2A is regulated and how methylation may alter its subcellular targeting and substrate specificity by influencing its interaction with regulatory subunits.

Citation: M. Mumby, A New Role for Protein Methylation: Switching Partners at the Phosphatase Ball. Sci. STKE 2001, pe1 (2001).

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