Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 24 April 2001
Vol. 2001, Issue 79, p. pe1
[DOI: 10.1126/scisignal.792001pe1]

PERSPECTIVES

A New Role for Protein Methylation: Switching Partners at the Phosphatase Ball

Marc Mumby

The author is in the Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041, USA. E-mail: marc.mumby{at}utsouthwestern.edu

Abstract: Reversible protein methylation may be another posttranslational modification that serves an important role in modulating signal transduction pathways. Not only does protein phosphatase 2A (PP2A), a key regulator of many signal transduction cascades, undergo this modification, but the methylation process itself may be regulated by various cellular stimuli or states. Mumby describes how PP2A is regulated and how methylation may alter its subcellular targeting and substrate specificity by influencing its interaction with regulatory subunits.

Citation: M. Mumby, A New Role for Protein Methylation: Switching Partners at the Phosphatase Ball. Sci. STKE 2001, pe1 (2001).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphoinositide 3-Kinase {gamma} Inhibits Cardiac GSK-3 Independently of Akt.
M. L. Mohan, B. K. Jha, M. K. Gupta, N. T. Vasudevan, E. E. Martelli, J. D. Mosinski, and S. V. Naga Prasad (2013)
Science Signaling 6, ra4
   Abstract »    Full Text »    PDF »
Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice.
R. Ruediger, J. Ruiz, and G. Walter (2011)
Mol. Cell. Biol. 31, 3832-3844
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882