Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 24 April 2001
Vol. 2001, Issue 79, p. tw9
[DOI: 10.1126/stke.2001.79.tw9]


Developmental Biology Sharing the Roundabout

The midline of the fruit fly and the zebrafish share more than just topology. Fricke et al. show that zebrafish use a receptor encoded by the gene astray for guiding axons from the developing eyes to the brain, crossing the midline on their way to form the optic chiasma. The astray receptor is similar to the receptor encoded by the gene roundabout that is responsible for guidance of growing axons across the midline in Drosophila. Chimeras made by exchanging eyes of mutant and wild-type zebrafish demonstrated that the relevant site of expression of astray is in the eye.

C. Fricke, J.-S. Lee, S. Geiger-Rudolph, F. Bonhoeffer, C.-B. Chien, astray, a Zebrafish roundabout homolog required for retinal axon guidance. Science 292, 507-510 (2001). [Abstract] [Full Text]

Citation: Sharing the Roundabout. Sci. STKE 2001, tw9 (2001).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882