Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 8 May 2001
Vol. 2001, Issue 81, p. pe1
[DOI: 10.1126/scisignal.812001pe1]

PERSPECTIVES

New Functions for DNA Binding Domains

Anjana Rao

The author is at the Center for Blood Research and the Department of Pathology, Harvard Medical School, Warren Alpert Building, 200 Longwood Avenue, Boston, MA 02115, USA. E-mail: arao{at}cbr.med.harvard.edu

Abstract: How the same transcription factor can be both an activator and a repressor of transcription is a biological mystery. Rao describes work that shows that the structure of the transcription factor may actually change depending on the DNA sequence bound by the factor. This change in structure may influence the binding of activators or repressors of transcription, thus allowing a single transcription factor to have two different activities.

Citation: A. Rao, New Functions for DNA Binding Domains. Sci. STKE 2001, pe1 (2001).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882