Sci. STKE, 8 May 2001
Fertility Helping with Her Coat
Phospholipase C (PLC) hydrolyzes a membrane phospholipid to produce two second messengers that can, in turn, function in cellular signaling pathways. Fukami et al. examined the PLC4 isoform, which is localized to the acrosomal region of sperm. When the PLC4 gene was disrupted in mice, the resultant males were either sterile or produced very few progeny. The sperm were unable to interact appropriately with the egg coat, the zona pellucida. Because PLC4 is essential for an early step in mammalian fertilization, greater insight into the function of this protein may aid in understanding human fertility and have application to contraception.
K. Fukami, K. Nakao, T. Inoue, Y. Kataoka, M. Kurokawa, R.A. Fissore, K. Nakamura, M. Katsuki, K. Mikoshiba, N. Yoshida, T. Takenawa, Requirement of phospholipase C4 for the zona pellucida-induced acrosome reaction. Science 292, 920-923. [Abstract] [Full Text]
Citation: Helping with Her Coat. Sci. STKE 2001, tw9 (2001).
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