Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 15 May 2001
Vol. 2001, Issue 82, p. pe1
[DOI: 10.1126/stke.2001.82.pe1]

PERSPECTIVES

CREB Signaling-Timing Is Everything

Soren Impey and Richard H. Goodman

The authors are at the Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA. E-mail: impeys{at}ohsu.edu

Abstract: Depolarization of neurons can lead to changes in gene expression that are important for such processes as synaptic plasticity, neuronal differentiation, and apoptosis. Impey and Goodman discuss some of the opposing models for how gene transcription in response to neuronal activity and elevations in intracellular calcium concentration is regulated. The pathways appear to converge on cyclic AMP response element-binding (CREB) protein, with the mitogen-activated protein kinase pathways playing an important role. The continuing debate about the involvement of calmodulin kinase IV is also described.

Citation: S. Impey, R. H. Goodman, CREB Signaling-Timing Is Everything. Sci. STKE 2001, pe1 (2001).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882