Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 29 May 2001
Vol. 2001, Issue 84, p. tw5
[DOI: 10.1126/stke.2001.84.tw5]

EDITORS' CHOICE

Neurobiology Metabolism, Excitability, and Seizures

Potassium channels that are sensitive to adenosine triphosphate (ATP) couple the intracellular metabolic state to electrical activity at the plasma membrane. Yamada et al. show in a knockout study that these channels exert a protective effect in the brain during hypoxia. Mice lacking ATP-sensitive K+-channels were more sensitive to generalized seizures. In slice experiments, neurons from knockout animals in the substantia nigra pars reticulata, an important brain area for the control of seizures, began to depolarize upon a hypoxic challenge rather than to hyperpolarize as do the neurons from normal control animals.

K. Yamada, J. J. Ji, H. Yuan, T. Miki, S. Sato, N. Horimoto, T. Shimizu, S. Seino, N. Inagaki, Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292, 1543-1546 (2001). [Abstract] [Full Text]

Citation: Metabolism, Excitability, and Seizures. Sci. STKE 2001, tw5 (2001).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882