Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 5 June 2001
Vol. 2001, Issue 85, p. pe1
[DOI: 10.1126/stke.2001.85.pe1]

PERSPECTIVES

Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis

Christopher E. Rudd

The author is in the Department of Pathology, Harvard Medical School, Boston MA 02115, USA, and the Department of Haematology, Imperial College School of Medicine, London, UK. E-mail: Christopher_Rudd{at}dfci.harvard.edu

Abstract: Originally thought to have the functions now ascribed to the linker for activation of T cells protein (LAT), Lnk is coming into its own as an adaptor protein that mediates signaling through several receptor pathways. An essential role for Lnk in B cell development and maturation was recently uncovered by Perlmutter and colleagues. Rudd discusses the role of Lnk in B cells and hypothesizes a mechanism whereby Lnk, and its closely related protein family members, the adaptor molecules containing pleckstrin homology (PH) and Src-homology 2 (SH2) domains (APS), and Src-homology 2-B protein (SH2-B), may mediate signal promotion or attenuation.

Citation: C. E. Rudd, Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis. Sci. STKE 2001, pe1 (2001).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke.
H. Ahlenius, K. Devaraju, E. Monni, K. Oki, S. Wattananit, V. Darsalia, R. E. Iosif, O. Torper, J. C. Wood, S. Braun, et al. (2012)
J. Neurosci. 32, 5151-5164
   Abstract »    Full Text »    PDF »
New mutations and pathogenesis of myeloproliferative neoplasms.
W. Vainchenker, F. Delhommeau, S. N. Constantinescu, and O. A. Bernard (2011)
Blood 118, 1723-1735
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882