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Sci. STKE, 5 June 2001
Vol. 2001, Issue 85, p. pe1
[DOI: 10.1126/stke.2001.85.pe1]


Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis

Christopher E. Rudd

The author is in the Department of Pathology, Harvard Medical School, Boston MA 02115, USA, and the Department of Haematology, Imperial College School of Medicine, London, UK. E-mail: Christopher_Rudd{at}

Abstract: Originally thought to have the functions now ascribed to the linker for activation of T cells protein (LAT), Lnk is coming into its own as an adaptor protein that mediates signaling through several receptor pathways. An essential role for Lnk in B cell development and maturation was recently uncovered by Perlmutter and colleagues. Rudd discusses the role of Lnk in B cells and hypothesizes a mechanism whereby Lnk, and its closely related protein family members, the adaptor molecules containing pleckstrin homology (PH) and Src-homology 2 (SH2) domains (APS), and Src-homology 2-B protein (SH2-B), may mediate signal promotion or attenuation.

Citation: C. E. Rudd, Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis. Sci. STKE 2001, pe1 (2001).

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