Sci. STKE, 19 June 2001
G Protein Signaling From Receptor to Nucleus
The binding of extracellular ligands to their receptors on the cell membrane can evoke a variety of responses, and in some cases, these responses include a change in gene expression and in transcription. Santagata et al. describe a new pathway in which occupancy of a plasma-membrane receptor results in mobilization of a transcription factor to the nucleus. In its inactive state, the protein Tubby, which has been connected to adult-onset obesity in mice, binds to the phosphorylated head group of a plasma-membrane lipid. When the G protein-coupled serotonin receptor is activated, phospholipase C hydrolyzes the lipid and releases Tubby, which then enters the nucleus, probably through its nuclear localization sequence. An intriguing suggestion is that this result may explain why serotonin-receptor knockout mice display symptoms of adult-onset obesity. Cantley writes a Perspective on the paper.
L. C. Cantley, Translocating Tubby. Science 292, 2019-2021 (2001). [Full Text]
Citation: From Receptor to Nucleus. Sci. STKE 2001, tw3 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882