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Sci. STKE, 26 June 2001
Vol. 2001, Issue 88, p. pe1
[DOI: 10.1126/stke.2001.88.pe1]

PERSPECTIVES

TGF-β Flips the Myc Switch

Amir Orian and Robert N. Eisenman

The authors are in the Division of Basic Sciences, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA. E-mail: eisenman{at}fhcrc.org

Abstract: Although transforming growth factor-β (TGF-β) can affect cell cycle arrest, not much molecular detail is known about how TGF-β-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15INK4b, and how TGF-β is able to unblock Myc-dependent repression of Miz-1.

Citation: A. Orian, R. N. Eisenman, TGF-β Flips the Myc Switch. Sci. STKE 2001, pe1 (2001).

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