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Sci. STKE, 31 July 2001
Vol. 2001, Issue 93, p. pe1
[DOI: 10.1126/stke.2001.93.pe1]

PERSPECTIVES

HOG on the Promoter: Regulation of the Osmotic Stress Response

Srikumar P. Chellappan

The author is in the Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Insititute, 12902 Magnolia Drive, Tampa, FL 33647, USA. E-mail: ChellaSP{at}moffitt.usf.edu

Abstract:

Members of the mitogen-activated protein (MAP) kinase family regulate transcription through phosphorylation of specific transcription factors. New studies indicate that this process may be more complex than previously anticipated. The yeast Hog1 protein kinase (a homolog of the mammalian p38 MAP kinase) interacts with transcription factors and perhaps with the general transcription machinery at target promoters. Chellappan discusses the recent results and their implications for understanding control of transcription by stress-activated MAP kinases.

Citation:
S. P. Chellappan, HOG on the Promoter: Regulation of the Osmotic Stress Response. Science's STKE (2001), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/93/pe1.

© 2001 American Association for the Advancement of Science

Citation: S. P. Chellappan, HOG on the Promoter: Regulation of the Osmotic Stress Response. Sci. STKE 2001, pe1 (2001).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)