Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 31 July 2001
Vol. 2001, Issue 93, p. pe1
[DOI: 10.1126/stke.2001.93.pe1]


HOG on the Promoter: Regulation of the Osmotic Stress Response

Srikumar P. Chellappan

The author is in the Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Insititute, 12902 Magnolia Drive, Tampa, FL 33647, USA. E-mail: ChellaSP{at}

Abstract: Members of the mitogen-activated protein (MAP) kinase family regulate transcription through phosphorylation of specific transcription factors. New studies indicate that this process may be more complex than previously anticipated. The yeast Hog1 protein kinase (a homolog of the mammalian p38 MAP kinase) interacts with transcription factors and perhaps with the general transcription machinery at target promoters. Chellappan discusses the recent results and their implications for understanding control of transcription by stress-activated MAP kinases.

Citation: S. P. Chellappan, HOG on the Promoter: Regulation of the Osmotic Stress Response. Sci. STKE 2001, pe1 (2001).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882