Sci. STKE, 14 August 2001
Immunology Sources of Receptor Specificity
The cytokine interleukin-5 (IL-5) induces the proliferation and differentiation of various blood cells through its receptor, IL-5R. Although the β subunit of the IL-5R is similar to other receptors, the α subunit is specific for IL-5 signaling. Geijsen et al. have explored IL-5 specificity and report that
N. Geijsen, I. J. Uings, C. Pals, J. Armstrong, M. McKinnon, J. A. M. Raaijmakers, J.-W. J. Lammers, L. Koenderman, P. J. Coffer, Cytokine-specific transcriptional regulation through an IL-5Rα interacting protein. Science 293, 1136-1138 (2001). [Abstract] [Full Text]
Citation: Sources of Receptor Specificity. Sci. STKE 2001, tw3 (2001).
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