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Sci. STKE, 14 August 2001
Vol. 2001, Issue 95, p. tw6
[DOI: 10.1126/stke.2001.95.tw6]

EDITORS' CHOICE

RIGHT-LEFT ASYMMETRY PKA Inhibitors in Development

Abstract:

cAMP-dependent protein kinase (PKA) functions in cell type determination in the embryos of Drosophila, zebrafish, and chicks. The {alpha} isoform of protein kinase inhibitor (PKI) inhibits the catalytic activity of PKA; however, the endogenous function of PKI{alpha} has not been well elucidated. Now, Kawakami and Nakanishi have uncovered a role for PKI{alpha} in cell patterning in the developing chick. During the early stages of development, PKI{alpha} expression was higher on the right side of Hensen's node in chick embryos; however, symmetric expression of PKI{alpha} was observed later in development. Treatment of chick embryos with antisense oligonucleotides to PKI{alpha} disrupted the placement of the developing heart and also caused perturbations in the expression of Nodal, and Pitx2, whereas asymmetric expression of Sonic Hedgehog remained normal. PKI{alpha} expression was stimulated in chick embryos ectopically treated with activin, suggesting that PKI{alpha} may act in an activin-dependent pathway to regulate asymmetric patterning.

M. Kawakami, N. Nakanishi, The role of an endogenous PKA inhibitor, PKI{alpha}, in organizing left-right axis formation. Development 128, 2509-2515 (2001). [Online Journal]

Citation: PKA Inhibitors in Development. Sci. STKE 2001, tw6 (2001).

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