Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 14 August 2001
Vol. 2001, Issue 95, p. tw7
[DOI: 10.1126/stke.2001.95.tw7]


Transcription Acetylation Flips the Transcription Switch

Cells respond to external challenges such as viral infection by adjusting gene expression. Viral infection activates the expression of interferon-β (INF-β) via a protein complex, termed the enhanceosome, that forms on the gene's promoter. The interferon enhanceosome recruits two acetyltransferases, PCAF and CBP, that not only acetylate the histone components of nucleosomes but also acetylate the enhanceosome itself. Munshi et al. (see the Perspective by Struhl) report that PCAF acetylation of the enhanceosome protein HMG-I at the Lys71 residue stabilizes the enhancesome and protects it from CBP acetylation. However, acetylation of HMG-I by CBP at Lys65 leads to the dissociation of the enhanceosome from the DNA molecule. Therefore, the enhanceosome is a dynamic complex that is acted upon by competing acetylations to create a switch that turns transcription on or off.

N. Munshi, T. Agalioti, S. Lomvardas, M. Merika, G. Chen, D. Thanos, Coordination of a transcriptional switch by HMGI(Y) acetylation. Science 293, 1133-1136 (2001). [Abstract] [Full Text]

K. Struhl, A paradigm for precision. Science 293, 1054-1055 (2001). [Full Text]

Citation: Acetylation Flips the Transcription Switch. Sci. STKE 2001, tw7 (2001).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882