Sci. STKE, 14 August 2001
Cell Differentiation Looks and Acts Like Sprouty
Two proteins identified by Wakioka et al. have been named Spred-1 and Spred-2 because they contain a Sprouty domain (SPR) and an Ena/VASP homology domain. Like Sprouty, the Spred proteins appear to inhibit growth factor-mediated stimulation of the Ras-MAP kinase pathway, and when overexpressed, they block differentiation of a neuron and muscle cell line. Endogenous Spred and Ras were found in a complex and also colocalized at the cell surface. Overexpression of Spred increased Ras-Raf interaction. The authors postulate that a Spred-induced increase in Ras-Raf interaction may somehow inhibit Raf activation.
T. Wakioka, A. Sasaki, R. Kato, T. Shouda, A. Matsumoto, K. Miyoshi, M. Tsuneoka, S. Komiya, R. Baron, A. Yoshimura, Spred is a Sprouty-related suppressor of Ras signalling. Nature 412, 647-651 (2001). [Online Journal]
Citation: Looks and Acts Like Sprouty. Sci. STKE 2001, tw8 (2001).
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