Sci. STKE, 21 August 2001
Calcium Channels Current Trends in Calcium Currents
Identification and characterization of new calcium channels that may function to control calcium-dependent signaling continues at a rapid pace. Sano et al. (see the Perspective by Levitan and Cibulsky) describe the human LTRP2 channel, a member of the transient receptor potential (TRP) family (see Review by Montell) that is abundantly expressed in the blood. The channel contains a motif in its cytoplasmic tail that is associated with nucleotide hydrolase activity. In cells transfected with LTRP2, conductance of the channel was directly activated by ADPR (adenosine diphosphate ribose), or β-NAD (β-nicotinamide adenine dinucleotide). In immunocyte cell lines, they observed a similar inward calcium current when cells were exposed to ADPR or β-NAD. In a Perspecitve, Levitan and Cibulsky summarize other recent work that has characterizing a different TRP-family member and in which different regulatory properties and ADPR pyrophosphatase activity are ascribed to LTRP2.
I. B. Levitan, S. M. Cibulsky, TRP ion channels--Two proteins in one. Science 293, 1270-1271 (2001). [Full Text]
C. Montell, Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science's STKE (2001), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/90/re1. [Full Text]
Citation: Current Trends in Calcium Currents. Sci. STKE 2001, tw3 (2001).
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