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Sci. STKE, 28 August 2001
Vol. 2001, Issue 97, p. pe1
[DOI: 10.1126/stke.2001.97.pe1]

PERSPECTIVES

IKK{alpha} on Center Stage

Joseph A. DiDonato

The author is in the Department of Cancer Biology, The Lerner Research Institute at The Cleveland Clinic, Cleveland, OH 44195, USA. E-mail: didonaj{at}ccf.org

Abstract:

Inhibitor of {kappa}B kinase {alpha} (IKK{alpha}) was originally identified as a component of a multiprotein kinase complex that regulates the activity of the transcription factor nuclear factor-{kappa}B (NF-{kappa}B) through phosphorylation of its inhibitor proteins, the I{kappa}Bs. DiDonato discusses new roles that have been discovered for IKK{alpha}, focusing especially on its role in epidermal differentiation and on a new function of IKK{alpha} in B cell maturation. In epidermal differentiation, IKK{alpha} regulates the production of a secreted differentiation factor through a pathway that is independent of its role in activation of NF-{kappa}B. In B cell maturation, conventional NF-{kappa}B signal-induced activation of IKK{alpha} results in phosphorylation of p100 precursor proteins and increased proteolytic processing and constitutive NF-{kappa}B activation.

Citation:
J. A. DiDonato, IKK{alpha} on Center Stage. Science's STKE (2001), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/97/pe1.

© 2001 American Association for the Advancement of Science

Citation: J. A. DiDonato, IKK{alpha} on Center Stage. Sci. STKE 2001, pe1 (2001).

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