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Sci. STKE, 28 August 2001
Vol. 2001, Issue 97, p. pe1
[DOI: 10.1126/scisignal.972001pe1]

PERSPECTIVES

IKKα on Center Stage

Joseph A. DiDonato

The author is in the Department of Cancer Biology, The Lerner Research Institute at The Cleveland Clinic, Cleveland, OH 44195, USA. E-mail: didonaj{at}ccf.org

Abstract: Inhibitor of {kappa}B kinase α (IKKα) was originally identified as a component of a multiprotein kinase complex that regulates the activity of the transcription factor nuclear factor-{kappa}B (NF-{kappa}B) through phosphorylation of its inhibitor proteins, the I{kappa}Bs. DiDonato discusses new roles that have been discovered for IKKα, focusing especially on its role in epidermal differentiation and on a new function of IKKα in B cell maturation. In epidermal differentiation, IKKα regulates the production of a secreted differentiation factor through a pathway that is independent of its role in activation of NF-{kappa}B. In B cell maturation, conventional NF-{kappa}B signal-induced activation of IKKα results in phosphorylation of p100 precursor proteins and increased proteolytic processing and constitutive NF-{kappa}B activation.

Citation: J. A. DiDonato, IKKα on Center Stage. Sci. STKE 2001, pe1 (2001).

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