Sci. STKE, 4 September 2001
Cardiac Development Sweet View of Heart Development
Cardiac valves are essential for normal heart function. Formation of the atrioventricular valve in the developing vertebrate heart involves complex but poorly defined signaling interactions between myocardial and endocardial cells at the boundary of the atrium and ventricle. Walsh and Stainier provide molecular insight into this process through their analysis of a zebrafish mutant called jekyll, which is severely defective in the initiation of heart valve formation. The mutated gene encodes UDP-glucose dehydrogenase (Ugdh), an enzyme required for production of hyaluronic acid and proteoglycans. Loss of Ugdh appears to disrupt the events that mark the valve-forming region as distinct from atrium and ventricle.
Citation: Sweet View of Heart Development. Sci. STKE 2001, tw11 (2001).
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