Sci. STKE, 4 September 2001
G Protein-Coupled Receptors Strengthening Blood Vessels
After an injury, the coagulation cascade goes into action to repair damaged tissue. When coagulation factors are eliminated in mouse embryos, the embryos die at mid-gestation and display extensive bleeding. Whether this is a result of defective platelet function or vascular defects has been unclear. Griffin et al. (see the Perspective by Carmeliet) have addressed this question by examining the role of PAR1, a G protein-coupled receptor that binds to and is cleaved by thrombin, a serine-protease coagulation factor. PAR1 is shown to be an endothelial factor and is needed for normal vascular development and integrity.
C. T. Griffin, Y. Srinivasan, Y.-W. Zheng, W. Huang, S. R. Coughlin, A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293, 1666-1670 (2001). [Abstract] [Full Text]
P. Carmeliet, Clotting factors build blood vessels. Science 293, 1602-1604 (2001). [Full Text]
Citation: Strengthening Blood Vessels. Sci. STKE 2001, tw9 (2001).
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