Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
GoGreen Membership

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 8 January 2002
Vol. 2002, Issue 114, p. pe1
[DOI: 10.1126/stke.2002.114.pe1]

PERSPECTIVES

IL-23: A Cytokine That Acts on Memory T Cells

David M. Frucht

The author is in the Laboratory of Cell Biology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

Summary: The newly discovered cytokine interleukin (IL)-23 shares some in vivo functions with IL-12, including the activation of the transcription factor STAT4 (signal tranducer and activator of transcription-4). Indeed, the receptors for each appear to share one subunit, but also have at least one distinct subunit. Frucht discusses the similarities of IL-12 and IL-23 and the effects that distinguish one from the other. In contrast to IL-12, IL-23 appears to participate in the proliferative signal in memory T cells. More functions that distinguish IL-23 from IL-12 are likely to be uncovered as soon as the other component(s) of the IL-23 receptor are molecularly cloned and characterized.

Contact information: E-mail: frucht{at}cber.fda.gov

Citation: D. M. Frucht, IL-23: A Cytokine That Acts on Memory T Cells. Sci. STKE 2002, pe1 (2002).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Role for the Cytoplasmic Adaptor Protein Act1 in Mediating IL-17 Signaling.
A. Linden (2007)
Sci. STKE 2007, re4
   Abstract »    Full Text »    PDF »

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)