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Sci. STKE, 8 January 2002
Vol. 2002, Issue 114, p. pe1
[DOI: 10.1126/stke.2002.114.pe1]

PERSPECTIVES

IL-23: A Cytokine That Acts on Memory T Cells

David M. Frucht

The author is in the Laboratory of Cell Biology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

Abstract: The newly discovered cytokine interleukin (IL)-23 shares some in vivo functions with IL-12, including the activation of the transcription factor STAT4 (signal tranducer and activator of transcription-4). Indeed, the receptors for each appear to share one subunit, but also have at least one distinct subunit. Frucht discusses the similarities of IL-12 and IL-23 and the effects that distinguish one from the other. In contrast to IL-12, IL-23 appears to participate in the proliferative signal in memory T cells. More functions that distinguish IL-23 from IL-12 are likely to be uncovered as soon as the other component(s) of the IL-23 receptor are molecularly cloned and characterized.

Contact information: E-mail: frucht{at}cber.fda.gov

Citation: D. M. Frucht, IL-23: A Cytokine That Acts on Memory T Cells. Sci. STKE 2002, pe1 (2002).

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