Sci. STKE, 8 January 2002
Neurobiology Molecular Basis of Mossy Fiber LTP
Long-term potentiation (LTP) at hippocampal mossy fiber synapses is distinct from most other forms of LTP. Mellor et al. found that the hyperpolarization-activated mixed cation current Ih unexpectedly plays an important role. Calcium entry into the hippocampal granule cells during repetitive stimulation activates a calcium-calmodulin-sensitive adenylate cyclase. The subsequent rise in adenosine 3',5'-monophosphate (cAMP) activates protein kinase A, which leads to increases in Ih. The resulting depolarization causes an enhancement of mossy fiber synaptic transmission.
Citation: Molecular Basis of Mossy Fiber LTP. Sci. STKE 2002, tw13 (2002).
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