Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 22 January 2002
Vol. 2002, Issue 116, p. pe4
[DOI: 10.1126/stke.2002.116.pe4]

PERSPECTIVES

A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain

Cam Patterson*

Carolina Cardiovascular Biology Center and Department of Medicine, Department of Pharmacology, and Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7126, USA.

Abstract: Ubiquitin ligases determine protein stability in a highly regulated manner by coordinating the addition of polyubiquitin chains to proteins that are then targeted to the proteasome for degradation. Ubiquitin ligases have generally been separated into two groups--those containing HECT domains and those with RING finger domains. Recently, a third group of ubiquitin ligases has emerged: those containing a U-box domain. Patterson discusses what is known about the few U-box-containing proteins that have been characterized, although the general properties of U-box proteins that distinguish them from other ubiquitin ligases are still a matter of speculation.

*Contact information. E-mail: cpatters{at}med.unc.edu

Citation: C. Patterson, A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain. Sci. STKE 2002, pe4 (2002).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
UUCD: a family-based database of ubiquitin and ubiquitin-like conjugation.
T. Gao, Z. Liu, Y. Wang, H. Cheng, Q. Yang, A. Guo, J. Ren, and Y. Xue (2013)
Nucleic Acids Res. 41, D445-D451
   Abstract »    Full Text »    PDF »
The ubiquitin-proteasome pathway and synaptic plasticity.
A. N. Hegde (2010)
Learn. Mem. 17, 314-327
   Abstract »    Full Text »    PDF »
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
E. J. Song, S. L. Werner, J. Neubauer, F. Stegmeier, J. Aspden, D. Rio, J. W. Harper, S. J. Elledge, M. W. Kirschner, and M. Rape (2010)
Genes & Dev. 24, 1434-1447
   Abstract »    Full Text »    PDF »
Regulation of adult bone mass by the zinc finger adapter protein schnurri-3..
D. C. Jones, M. N. Wein, M. Oukka, J. G. Hofstaetter, M. J. Glimcher, and L. H. Glimcher (2006)
Science 312, 1223-1227
   Abstract »    Full Text »    PDF »
A Bacterial Inhibitor of Host Programmed Cell Death Defenses Is an E3 Ubiquitin Ligase.
R. Janjusevic, R. B. Abramovitch, G. B. Martin, and C. E. Stebbins (2006)
Science 311, 222-226
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882