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Sci. STKE, 22 January 2002
Vol. 2002, Issue 116, p. pe4
[DOI: 10.1126/stke.2002.116.pe4]


A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain

Cam Patterson*

Carolina Cardiovascular Biology Center and Department of Medicine, Department of Pharmacology, and Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7126, USA.

Abstract: Ubiquitin ligases determine protein stability in a highly regulated manner by coordinating the addition of polyubiquitin chains to proteins that are then targeted to the proteasome for degradation. Ubiquitin ligases have generally been separated into two groups--those containing HECT domains and those with RING finger domains. Recently, a third group of ubiquitin ligases has emerged: those containing a U-box domain. Patterson discusses what is known about the few U-box-containing proteins that have been characterized, although the general properties of U-box proteins that distinguish them from other ubiquitin ligases are still a matter of speculation.

*Contact information. E-mail: cpatters{at}

Citation: C. Patterson, A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain. Sci. STKE 2002, pe4 (2002).

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