Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 22 January 2002
Vol. 2002, Issue 116, p. tw33
[DOI: 10.1126/stke.2002.116.tw33]

EDITORS' CHOICE

Neurobiology Trauma, Stress, and Consequences

Traumatic stress often causes long-term pathological changes. To elucidate the molecular basis of these stress-induced changes, Meshorer et al. analyzed the regulation of expression of acetylcholinesterase (AChE) splice variants at cholinergic synapses in the central nervous system. They saw a change from the dominant membrane-bound AChE-S form to the rare soluble AChE-R form. This switch could be triggered by various stresses, occurred very rapidly, and could last for many weeks.

E. Meshorer, C. Erb, R. Gazit, L. Pavlovsky, D. Kaufer, A. Friedman, D. Glick, N. Ben-Arie, H. Soreq, Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science 295, 508-512 (2002). [Abstract] [Full Text]

Citation: Trauma, Stress, and Consequences. Sci. STKE 2002, tw33 (2002).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882