Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 29 January 2002
Vol. 2002, Issue 117, p. tw49
[DOI: 10.1126/stke.2002.117.tw49]

EDITORS' CHOICE

Apoptosis Another IAP

Inhibitors of apoptosis proteins (IAPs) block cell death by interacting with and inhibiting caspases. IAP-inhibitory proteins work in opposition to induce cell death. Such inhibitors are present in both mammals and fruit flies, and all contain an amino-terminal IAP binding motif that is thought to disrupt caspase-IAP interaction. Three groups have identified another IAP-inhibitory protein called Sickle (Skl) in Drosophila. Skl is expressed predominantly in the fly central nervous system during development. Like other IAP inhibitors, Skl also interacted with and inhibited the caspase-inhibiting activity of IAPs in vitro. Skl induced cell death when overexpressed in cultured mammalian or fly cells. However, only coexpression of Skl with another IAP-inhibitor caused defective eye development. In a Drosophila mutant that expresses normal amounts of Sickle, but lacks the three other IAP inhibitors, Reaper, Hid, and Grim, there was little observed cell death. The studies suggest that Sickle may synergize with other family members to induce its apoptotic effect.

S. M. Srinivasula, P. Datta, M. Kobayashi, J.-W. Wu, M. Fujioka, R. Hegde, Z. Zhang, R. Mukattash, T. Fernandes-Alnemri, Y. Shi, J. B. Jaynes, E. S. Alnemri, sickle, a novel Drosophila death gene in the reaper/hid/grim regions, encodes an IAP-inhibitory protein. Curr. Biol. 12, 125-130 (2002). [Online Journal]

J. P. Wing, J. S. Karres, J. L. Ogdahl, L. Zhou, L. M. Schwartz, J. R. Nambum, Drosophila sickle is a novel grim-reaper cell death activator. Curr. Biol. 12, 131-135 (2002). [Online Journal]

A. Christich, S. Kauppila, P. Chen, N. Sogame, S.-I. Ho, J. M. Abrams, The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr. Biol. 12, 137-140 (2002). [Online Journal]

Citation: Another IAP. Sci. STKE 2002, tw49 (2002).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882