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Sci. STKE, 19 February 2002
Vol. 2002, Issue 120, p. pe8
[DOI: 10.1126/stke.2002.120.pe8]


The SAP Family: A New Class of Adaptor-Like Molecules That Regulates Immune Cell Functions

André Veillette*

Laboratory of Molecular Oncology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada; Department of Medicine, University of Montréal, Montréal, Québec, Canada; and the McGill Cancer Centre and Department of Biochemistry, Department of Medicine, and Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.

Abstract: EAT-2 is a member of a newly described adaptor-like protein family consisting, at the moment, of EAT-2 and the signaling lymphocytic-activation molecule (SLAM)-associated protein (SAP). Both proteins are expressed in immune cells and can bind to members of the SLAM family of immune receptors. However, differences between the two proteins exist. There appears to be little overlap in the types of immune cells that express SAP and EAT-2, and the Src homology 2 (SH2) domain of SAP can bind to unphosphorylated tyrosines, whereas the SH2 domain of EAT-2 cannot. Veillette discusses new findings on the functions of EAT-2 and SAP and how they might regulate signals emanating from the SLAM family of receptors.

*Contact information. Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montréal, Québec, Canada H2W 1R7. E-mail: veillea{at}

Citation: A. Veillette, The SAP Family: A New Class of Adaptor-Like Molecules That Regulates Immune Cell Functions. Sci. STKE 2002, pe8 (2002).

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