Sci. STKE, 19 February 2002
Protein Modification Doing Double Duty
Regulation of the cell cycle involves the nedd8 ubiquitin-like modification of key proteins. Kurz et al. now find that these modifications are also important in controlling the cytoskeleton in Caenorhabditis elegans embryos. Nedd 8 conjugation inhibits microfilament contraction in the cell cortex during pronuclear migration and again during cytokinesis. In addition, katanin, a microtubule-severing complex, is degraded after neddylation at the end of meiosis.
T. Kurz, L. Pintard, J. H. Wills, D. R. Hamill, P. Gönczy, M. Peter, B. Bowerman, Cytoskeletal regulation by the nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298 (2002). [Abstract] [Full Text]
Citation: Doing Double Duty. Sci. STKE 2002, tw78 (2002).
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