Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 26 February 2002
Vol. 2002, Issue 121, p. pe9
[DOI: 10.1126/stke.2002.121.pe9]


The Dawn of the SPPARMs?

Shamina M. Rangwala and Mitchell A. Lazar*

Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

Abstract: Thiazolidinediones (TZDs) are used as antidiabetic agents in the treatment of type II diabetes. These compounds are ligands for the nuclear hormone receptor PPAR{gamma}, which is highly expressed in adipose tissue. PPAR{gamma} acts as a molecular switch in the process of fat cell development. The quest for the ideal antidiabetic agent is challenged by the need to develop PPAR{gamma} ligands that improve insulin sensitivity, but do not promote fat cell formation. A newly described PPAR{gamma} ligand may represent an initial step in this direction and could lead to improved agents for treating insulin resistance in type II diabetes.

*Author contact information. University of Pennsylvania School of Medicine, 611 CRB, 415 Curie Boulevard, Philadelphia, PA 19104-6149, USA. Telephone: (215) 898-0198, fax: (215) 898-5408, e-mail: lazar{at}

Citation: S. M. Rangwala, M. A. Lazar, The Dawn of the SPPARMs? Sci. STKE 2002, pe9 (2002).

Read the Full Text

Nuclear Receptors and Their Selective Pharmacologic Modulators.
T. P. Burris, L. A. Solt, Y. Wang, C. Crumbley, S. Banerjee, K. Griffett, T. Lundasen, T. Hughes, and D. J. Kojetin (2013)
Pharmacol. Rev. 65, 710-778
   Abstract »    Full Text »    PDF »
N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor {gamma} Ligand with Partial and Full Agonist Activity in Vitro and in Vivo.
K. Bhalla, B. J. Hwang, J. H. Choi, R. Dewi, L. Ou, J. Mclenithan, W. Twaddel, E. Pozharski, J. Stock, and G. D. Girnun (2011)
J. Biol. Chem. 286, 41626-41635
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882