Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 26 February 2002
Vol. 2002, Issue 121, p. tw80
[DOI: 10.1126/stke.2002.121.tw80]

EDITORS' CHOICE

Immunology After the Signal's Gone, What's Left?

T cells are stimulated into action when they associate with other immune cells that present them with specific antigens. An intercellular synapse facilitates this intimate encounter and a prolonged engagement is thought to be required for T cell activation. Lee et al. (see the Perspective by van der Merwe and Davis) in fact show that signaling through the T cell receptor has abated by the time a mature immunological synapse has formed. The center of the mature synapse may not function as a supramolecular signaling complex as previously thought, which raises new questions about the function of this specialized and dynamic structure.

K.-H. Lee, A. D. Holdorf, M. L. Dustin, A. C. Chan, P. M. Allen, A. S. Shaw, T cell receptor signaling precedes immunological synapse formation. Science 295, 1539-1542 (2002). [Abstract] [Full Text]

P. A. van der Merwe, S. J. Davis, The immunological synapse--a multitasking system. Science 295, 1479-1480 (2002). [Full Text]

Citation: After the Signal's Gone, What's Left? Sci. STKE 2002, tw80 (2002).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882