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Sci. STKE, 12 March 2002
Vol. 2002, Issue 123, p. pe12
[DOI: 10.1126/stke.2002.123.pe12]

PERSPECTIVES

Molecular BKology: The Study of Splicing and Dicing

Matthew Fury1, Steven O. Marx1,2, and Andrew R. Marks1,2*

1Center for Molecular Cardiology, Department of Pharmacology, and Division of Cardiology, New York, NY 10032, USA.
2Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Abstract: The activity of ion channels is regulated by several different mechanisms. Studies have been undertaken to determine how the large-conductance Ca2+-sensitive K+ channel (the BK channel) is regulated. Fury et al. discuss how the presence or absence of alternatively spliced regions in the BK channel α subunit can act as a molecular switch by which different kinases activate the BK channel.

*Corresponding author. E-mail: arm42{at}columbia.edu

Citation: M. Fury, S. O. Marx, A. R. Marks, Molecular BKology: The Study of Splicing and Dicing. Sci. STKE 2002, pe12 (2002).

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