Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 12 March 2002
Vol. 2002, Issue 123, p. tw103
[DOI: 10.1126/stke.2002.123.tw103]


Redox Regulation A Sense of Cell

The transcription factor CtBP associates with transcriptional repressors for the regulation of genes involved in development, cell cycle regulation, and transformation. Zhang et al. show that the corepressor activity of CtBP can be regulated by the redox state of the cell. Mammalian CtBP is regulated by physiological concentrations of nuclear nicotinamide adenine dinucleotides (NADs). When the nuclear concentration of free NAD and NADH increases, CtBP increases its affinity for viral and cellular repressors and represses transcription. This regulatory mechanism suggests how protein interactions might respond to metabolic balances for the regulation of transcription.

Q. Zhang, D. W. Piston, R. H. Goodman, Regulation of corepressor function by nuclear NADH. Science 295, 1895-1897 (2002). [Abstract] [Full Text]

Citation: A Sense of Cell. Sci. STKE 2002, tw103 (2002).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882