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Sci. STKE, 19 March 2002
Vol. 2002, Issue 124, p. pe14
[DOI: 10.1126/stke.2002.124.pe14]


Dancing with Multiple Partners

Darren G. Woodside*

Texas Biotechnology Corporation, 7000 Fannin, Houston, TX 77030, USA.

Abstract: Transmembrane proteins, such as G protein-coupled receptors (GPCRs) and integrins, activate intracellular signaling pathways through interactions with downstream binding partners. Woodside discusses two examples in which GPCRs and integrins interact in a noncompeting manner with more than one partner. The specific GPCR described is the thrombin receptor, in experiments where G protein peptides selectively block signaling through a particular G protein that does not appear to inhibit coupling of the receptor to other G proteins. The second system described is the αIIbβ3 integrin and its activation of the nonreceptor tyrosine kinase Syk. Syk appeared capable of interacting with both the integrin and intracellular domains of immune response receptors, because binding of Syk to the integrin was not inhibited by peptides based on the Syk binding site in immune response receptors. Thus, multiple, noncompeting binding partners add to the complexity of signal transduction outputs from a single receptor complex.

*Contact information. E-mail: dwoodside{at}

Citation: D. G. Woodside, Dancing with Multiple Partners. Sci. STKE 2002, pe14 (2002).

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Syk, c-Src, the {alpha}v{beta}3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
W. Zou, H. Kitaura, J. Reeve, F. Long, V. L.J. Tybulewicz, S. J. Shattil, M. H. Ginsberg, F. P. Ross, and S. L. Teitelbaum (2007)
J. Cell Biol. 176, 877-888
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