Sci. STKE, 19 March 2002
Plant Immunity Protein Degradation Maintains Plant Defenses
The innate immune response by which plants defend against certain pathogens includes interactions between a signal from the pathogen and a specific resistance (R) gene in the plant. Although there are a variety of R genes, and a veritable multitude of pathogens, the plant tends to respond with a limited repertoire of physiological responses. Azevedo et al. and Austin et al. analyze the signaling cascade initiated by activation of disease resistance (see the Perspective by Nishimura and Somerville). Several R proteins trigger responses through the RAR1 protein, which in turn interacts with the SGT1 proteins. These results implicate SGT1 in ubiquitin-targeted protein degradation. The two SGT1 variants in Arabidopsis seem to have divergent functions. Thus, at least part of the signaling cascade triggered by response to a pathogen may involve protein degradation.
C. Azevedo, A. Sadanandom, K. Kitagawa, A. Freialdenhoven, K. Shirasu, P. Schulze-Lefert, The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295, 2073-2076 (2002). [Abstract] [Full Text]
Citation: Protein Degradation Maintains Plant Defenses. Sci. STKE 2002, tw112 (2002).
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