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Sci. STKE, 26 March 2002
Vol. 2002, Issue 125, p. tw122
[DOI: 10.1126/stke.2002.125.tw122]

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Neurobiology Presynaptic Calcium Influx

Neurotransmitter release is triggered by calcium influx through presynaptic voltage-dependent calcium channels. Modulation of presynaptic calcium currents causes a robust alteration in synaptic efficacy. Tsujimoto et al. investigated activity-dependent facilitation of P/Q-type calcium currents at the giant nerve terminals of the calyx of Held and found that calcium current up-regulation is mediated by the calcium-binding protein NCS-1, a homolog of the Drosophila frequenin protein.

T. Tsujimoto, A. Jeromin, N. Saitoh, J. C. Roder, T. Takahashi, Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium current at presynaptic nerve terminals. Science 295: 2276-2279 (2002). [Abstract] [Full Text]

Citation: Presynaptic Calcium Influx. Sci. STKE 2002, tw122 (2002).


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