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Sci. STKE, 2 April 2002
Vol. 2002, Issue 126, p. tw127
[DOI: 10.1126/scisignal.1262002tw127]

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Aging Linking the Elements of Agents

Three components that have each been associated separately with the aging process in worm or rodent model systems have now been linked together by Nemoto and Finkel in a mammalian signaling pathway that may regulate longevity. An increase in intracellular oxidants decreased the activity of a forkhead transcription factor, whose inhibition has been implicated in aging. This effect required expression of the intracellular protein p66shc. Preservation of forkhead activity resulted in higher oxidant scavenging and a decrease on overall cellular oxidant levels. The use of reactive oxygen species as signaling agents may have important therapeautic implications.

S. Nemoto, T. Finkel, Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295: 2450-2452 (2002). [Abstract] [Full Text]

Citation: Linking the Elements of Agents. Sci. STKE 2002, tw127 (2002).

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