Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 16 April 2002
Vol. 2002, Issue 128, p. tw142
[DOI: 10.1126/stke.2002.128.tw142]

Physiology Powering Up Muscle

Endurance training enhances the oxidative capacity of skeletal muscle by stimulating the production of mitochondria, the organelles that supply fuel to cells. The molecular signals that mediate this adaptive process are not well understood. Through a study of transgenic mice that express a hyperactive form of calcium, calmodulin-dependent protein kinase IV (CaMKIV) in their skeletal muscle, Wu et al. establish that calcium-regulated signaling pathways play a key in controlling mitochondrial biogenesis in muscle.

H, Wu, S. B. Kanatous, F. A. Thurmond, T. Gallardo, E. Isotani, R. Bassel-Duby, R. S. Williams, Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296, 349-352 (2002). [Abstract] [Full Text]

Citation: Powering Up Muscle. Sci. STKE 2002, tw142 (2002).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882