Do Defects in Ion Channel Glycosylation Set the Stage for Lethal Cardiac Arrhythmias?

doi:10.1126/stke.2002.130.pe19

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Sci. STKE, 30 April 2002
Vol. 2002, Issue 130, p. pe19
[DOI: 10.1126/stke.2002.130.pe19]

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Do Defects in Ion Channel Glycosylation Set the Stage for Lethal Cardiac Arrhythmias?

Harry A. Fozzard^* and John W. Kyle

Cardiac Electrophysiology Laboratories, Departments of Medicine and of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA.

Summary: Many ion channels are modified by the addition of carbohydrate residues. Fozzard and Kyle discuss evidence that sialic acid residues on glycosylated cardiac sodium and potassim channels may be important for preventing early after-depolarizations that can result in cardiac arrhythmias.

*Corresponding author. MC6094, University of Chicago Hospitals, 5841 South Maryland Avenue, Chicago, IL 60637, USA. Telephone, 773-702-1481; fax, 773-702-6789; e-mail, foz{at}hearts.bsd.uchicago.edu

Citation: H. A. Fozzard, J. W. Kyle, Do Defects in Ion Channel Glycosylation Set the Stage for Lethal Cardiac Arrhythmias? Sci. STKE 2002, pe19 (2002).

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