Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 7 May 2002
Vol. 2002, Issue 131, p. pe22
[DOI: 10.1126/stke.2002.131.pe22]

PERSPECTIVES

Death Receptor Signaling Giving Life to Ectodermal Organs

Irma Thesleff* and Marja L. Mikkola

Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, Post Office Box 56, University of Helsinki, 00014 Helsinki, Finland.

Abstract: A new tumor necrosis factor (TNF) pathway has been identified that has an important function in the regulation of embryonic development. Three key components of this pathway are previously unknown proteins: the TNF ligand ectodysplasin (also known as EDA), its death domain-containing receptor EDAR, and the death domain adapter molecule EDARADD. This pathway was discovered and delineated through the cloning of genes that cause human hypohidrotic ectodermal dysplasia (HED) syndromes and by analysis of the corresponding mouse mutants (Tabby, downless, and crinkled) showing defects in hair, teeth, and several exocrine glands. EDAR signaling is mediated by the activation of nuclear factor kappa B, but other downstream targets are not known. Ectodysplasin-EDAR signaling mediates cell interactions within the ectoderm and regulates the initiation and morphogenesis of hair and teeth. It is also necessary for the development of fish scales, indicating that this pathway and its function have been conserved during the evolution of ectodermal organs.

*Corresponding author. E-mail: irma.thesleff{at}helsinki.fi

Citation: I. Thesleff, M. L. Mikkola, Death Receptor Signaling Giving Life to Ectodermal Organs. Sci. STKE 2002, pe22 (2002).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.
J. Laurikkala, M. L. Mikkola, M. James, M. Tummers, A. A. Mills, and I. Thesleff (2006)
Development 133, 1553-1563
   Abstract »    Full Text »    PDF »
Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles.
P. F. Colosimo, K. E. Hosemann, S. Balabhadra, G. Villarreal Jr., M. Dickson, J. Grimwood, J. Schmutz, R. M. Myers, D. Schluter, and D. M. Kingsley (2005)
Science 307, 1928-1933
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882